Cambridge Healthtech Instituteの初開催

Biologics for Immunology Indications
適応免疫向けバイオロジクス

New Science and Conversations to Empower the Next Wave of Immunological Therapies
免疫療法の次なる波を活性化させる新しい科学と対話

2025年5月12日 - 13日 EDT(米国東部標準時・夏時間)

PEGSの初開催となる「適応免疫向けバイオロジクス」会議では、研究科学者向けに、免疫疾患の前臨床研究における最新の進歩を探究するプラットフォームを提供します。この会議では、自己免疫、慢性炎症、希少疾患などの複雑な病態に対処する新しい戦略に焦点を当てます。出席者は、免疫経路を標的とし、新規の治療戦略を策定する革新的アプローチを掘り下げます。このセッションでは、バイオロジクス開発の進展を促進する初期段階の研究の実用的側面に焦点を当て、コラボレーションと知識の交換を促進することを目的としています。

Sunday, May 11

1:00 pmMain Conference Registration

2:00 pmRecommended Pre-Conference Short Course

SC2: Safety & Efficacy of Bispecifics and ADCs

*Separate registration required. See short course page for details.

Monday, May 12

7:00 amRegistration and Morning Coffee

MODULATING IMMUNE CHECKPOINTS AND EFFECTOR CELLS

8:20 am

Chairperson's Remarks

Michael Leney-Greene, PhD, Investigator, Biology, AI Proteins

8:30 am

Disrupting B and T Cell Collaboration in Autoimmune Disease: T Cell Engagers versus CAR T Cell Therapy?

Venkat Reddy, PhD, Associate Professor, Rheumatology, University College London

B and T cells collaborate to drive autoimmune disease (AID). Anti-CD20 antibodies provide targeted B-cell depletion (BCD), but some patients have refractory AID due to incomplete BCD. Novel therapies using T cells as effectors may disrupt B-T cell collaboration and overcome rituximab-resistant AID.

9:00 am

SAB03, a Highly Potent Multi-MOA mAb for the Depletion of Pathogenic T Cells in Autoimmune Diseases

Peter Emtage, PhD, CEO, Santa Ana Bio

T cell activation is strictly regulated to allow for the development of adaptive immune responses. Excessive T cell activation underpins many autoimmune diseases. At the heart of the activation paradigm are co-stimulatory molecules, for example CD28, that act with signals from the T cell receptor (TCR) to promote adaptive immunity. Conversely, inhibitory receptors, for example, cytotoxic T lymphocyte associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) down-regulate T cell receptor (TCR) activation levels limiting adaptive immune responses and unwanted normal tissue damage. SAB03 is an anti PD-1 agonistic monoclonal antibody with a fully enabled Fc domain for the suppression and depletion of PD-1+pathogenic T cells.

9:30 am

Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases

Jamie B. Spangler, PhD, Associate Professor, Biomedical and Chemical & Biomolecular Engineering, Johns Hopkins University

The interleukin-2 (IL-2) cytokine plays an essential role in preventing the development of autoimmune disorders by supporting growth and activity of regulatory T cells (Tregs). IL-2 has great potential for autoimmune disease mitigation; however, its simultaneous stimulation of effector immune cells and short half-life limit clinical promise. We developed cytokine/antibody fusion proteins that bias IL-2 towards Tregs while also extending half-life, leading to clinically promising therapies to treat autoimmune diseases.

10:00 amSponsored Presentation (Opportunity Available)

10:30 amNetworking Coffee Break

FcRn INHIBITION

11:00 am

Nipocalimab: A High-Affinity, Immunoselective FcRn Blocker as an Investigational Therapy for IgG-Driven Autoimmune and Alloimmune Diseases

Nilufer Seth, PhD, Senior Scientific Director and Head, Discovery, Autoantibody Portfolio and Maternal Fetal Disease Area, Johnson & Johnson Innovative Medicine

Nipocalimab is a fully human IgG1 monoclonal antibody that exhibits high specificity and affinity for the neonatal Fc receptor at both neutral and acidic pH. Nipocalimab facilitates a significant reduction in circulating IgG levels, including pathogenic IgG, which is implicated in various IgG-driven auto- and allo- antibody diseases. This investigational therapy is being evaluated across three critical disease segments: Rare Autoantibody-ranging from neurologic to hematologic diseases; Maternal Fetal Immunology and Prevalent Rheumatological autoantibody-driven diseases, in multiple potential indications, each with high unmet need. This presentation will delve into its molecular properties and highlight pivotal clinical data.

11:30 am

Stepwise Design of a Next Generation FcRn Inhibitor Fused to an Albumin-Binder Results in Potent IgG Reduction

Vladimir Bobkov, PhD, Principal Scientist, Preclinical Product Development, argenx BVBA

Neonatal Fc receptor is a popular target for treatment of autoimmune disorders due to its role in maintaining IgG levels. Fc-ABDEG and albumin-binding VHH were combined to develop next-generation FcRn blockers with improved IgG clearance. Step-wise engineering was applied to optimize position and number of VHHs, their affinity to albumin, and the linker connecting it to Fc-ABDEG. Novel FcRn-based cellular assays and human FcRn transgenic mice will also be addressed.

12:00 pmSession Break

12:10 pm Talk Title to be Announced

Speaker to be Announced, Nona Biosciences

12:40 pmLuncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:10 pmSession Break

EMERGING TARGETING STRATEGIES

1:15 pm

Chairperson's Remarks

Joel Goldstein, PhD, Executive Director R&D, Celldex Therapeutics

1:20 pm

Characterization of the First de novo Miniprotein Inhibitors of TNFR1 for the Treatment of Inflammatory Disease

Michael Leney-Greene, PhD, Investigator, Biology, AI Proteins

Specific inhibition of TNF receptor 1 has been challenging using conventional antibody-based therapeutics, due to potentially dangerous agonistic activity. We have successfully generated de novo miniproteins that specifically inhibit TNFR1 but not TNFR2 with picomolar affinity in vitro and in vivo, blocking pathogenic TNF-a signaling. This work reveals a novel mechanism of action for alleviating autoimmune disease by blocking TNFR1 activity while regulatory beneficial signaling through TNFR2 remains intact.

1:50 pm

KnotBodies: Creating Ion Channel-Modulating Antibodies by Fusing Knottins into Antibody Loops

John D. McCafferty, PhD, CTO and Founder, Maxion Therapeutics

Venom-derived cysteine-rich miniproteins (knottins) have potential as therapeutic agents to block ion channels, but suffer from manufacturing difficulties, short half-lives, and a lack of specificity. Maxion has developed a novel molecular format wherein a peripheral CDR loop of an antibody has been replaced by a knottin. This format, termed a KnotBody, combines the benefits of both scaffolds with the antibody gaining the functionality of a scaffold pre-disposed to the blockade of ion channels-and the knottin enjoying the extended half-life and the additional specificity conferred by the antibody molecule. This presentation illustrates the generation and optimization of KnotBody inhibitors.

2:20 pm

Dual Inhibition of Mast Cells and TSLP for Inflammatory Disorders Using a Novel Bispecific Antibody, CDX-622

Joel Goldstein, PhD, Executive Director R&D, Celldex Therapeutics

Mast cells (MCs) play a significant role in various immune-related disorders. Their survival depends on KIT receptor activation by Stem Cell Factor (SCF). TSLP neutralization has demonstrated activity in asthma. CDX-622, a bispecific antibody, neutralized both SCF and TSLP in functional assays and resulted in MC depletion in a non-human primate study. CDX-622 offers potential benefits by targeting complementary pathways in chronic inflammation. A phase 1 clinical study is underway.

2:50 pmSponsored Presentation (Opportunity Available)

3:20 pmNetworking Refreshment Break

4:05 pmTransition to Plenary Keynote Session

PLENARY KEYNOTE SESSION

4:15 pm

Plenary Keynote Introduction

Jennifer R. Cochran, PhD, Senior Associate Vice Provost for Research and Macovski Professor of Bioengineering, Stanford University

4:25 pm

The Role of Protein Engineering in Developing New Innovative Modalities    

Puja Sapra, PhD, Senior Vice President, Head R&D Biologics, Engineering and Oncology Targeted Discovery, AstraZeneca

Advances in protein engineering technologies have revolutionized biologics design, paving the way for new innovative drug modalities. This talk will highlight key advancements in the field of protein engineering that have enabled these new modalities to enter the clinic and provide benefit to patients. The talk will also explore the impact of machine learning-enabled deep screening technology on hit identification, lead optimization and development of antibody-based therapies.      

YOUNG SCIENTIST KEYNOTE

5:10 pm

Antibody-Lectin Chimeras for Glyco-Immune Checkpoint Blockade

Jessica C. Stark, PhD, Underwood-Prescott Career Development Professor, MIT

Despite the curative potential of cancer immunotherapy, most patients do not benefit from treatment. Glyco-immune checkpoints-interactions of cancer glycans with inhibitory glycan-binding receptors called lectins-have emerged as prominent mechanisms of resistance to existing immunotherapies. I will describe development of antibody-lectin chimeras: a biologic framework for glyco-immune checkpoint blockade that is now moving toward the clinic.

5:55 pmWelcome Reception in the Exhibit Hall with Poster Viewing

YOUNG SCIENTIST MEET-UP

6:30 pm

Co-Moderators:

Iris Goldman, Production, Cambridge Innovation Institute

Garrett Rappazzo, PhD, Scientist, Platform Technologies, Adimab

Julie Sullivan, Production, Cambridge Innovation Institute

7:20 pmClose of Day

Tuesday, May 13

7:30 amRegistration and Morning Coffee

MENTORING MEET-UP

7:31 am

Creating and Fostering a Productive and Effective Mentor-Mentee Relationship

Carter A. Mitchell, PhD, CSO, Purification & Expression, Kemp Proteins, LLC

Deborah Moore-Lai, PhD, Vice President, Protein Sciences, ProFound Therapeutics

This meet-up is designed for senior scientists that are interested in becoming a mentor for junior scientists: IN-PERSON ONLY

  • What it takes to be a mentor
  • Finding the right match
  • Goal of Mentoring is to provide support for professional career development and informal coaching
  • The Mentor:Mentee relationship: you get out of it what you put into it.
  • Establishing boundaries and clear action items to make the most of the experience.
8:30 am

Chairperson's Remarks

Nilufer Seth, PhD, Senior Scientific Director and Head, Discovery, Autoantibody Portfolio and Maternal Fetal Disease Area, Johnson & Johnson Innovative Medicine

8:35 am

KEYNOTE PRESENTATION: Modulating Inflammation through Cytokine Engineering

Jeffrey A. Hubbell, PhD, Professor, Chemical and Biomolecular Engineering, New York University

The immune system exists in a delicate balance of mounting effector responses to pathogens while existing in an active state of tolerance to self. We are developing approaches for targeting inflammatory cytokines as well as chemokines to the tumor microenvironment and for targeting anti-inflammatory cytokines to the lymph nodes that drain sites of inflammation. These, respectively, show promise in mouse models of solid tumors and of autoimmune conditions.

BIOTHERAPEUTICS FOR UNMET AND UNDERSERVED MEDICAL NEEDS

9:05 am

An Oral Antibody for Inflammatory Bowel Disease

James T. Koerber, PhD, Distinguished Scientist and Director, Antibody Engineering, Genentech, Inc.

Existing IBD therapeutics exhibit high costs, systemic safety risks, and require injections. Here, we present a workflow to develop oral VHHs via simultaneous optimization of the affinity and protease stability. This oral VHH matches the efficacy of an injected antibody in a murine colitis model and exerts a strong pharmacodynamic effect in non-human primates. With high potency, gut stability, and favorable developability, oral VHHs offer a promising approach for IBD.

9:35 am

DONQ52 Multispecific Antibody against HLADQ2.5/Gluten Peptide Complex for Celiac Disease

Noriyuki Takahashi, Director, Lead Identification, Chugai Pharmabody Research Pte Ltd.

Complex of HLA-DQ2.5/gluten peptides elicits gluten-specific CD4+ T cells activation in celiac disease patients. DONQ52 is a novel multispecific antibody aimed to bind cross-reactively to multiple gluten peptide loaded HLA-DQ2.5. DONQ52 has potential to neutralize immune response to gluten. Here we introduce antibody engineering strategy, including lead identification and lead optimization as well as broad reactive characteristics of DONQ52.

10:05 amSponsored Presentation (Opportunity Available)

10:35 amCoffee Break in the Exhibit Hall with Poster Viewing

11:15 am

Post-Translational Modified Insulin Neoepitopes-Potential New Precision Targets in Type 1 Diabetes Diagnosis and Treatment

Ahuva Nissim, PhD, Professor, Antibody and Therapeutic Engineering, William Harvey Research Institute, Queen Mary University of London

Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with Type 1 diabetes (T1D), even before the clinical onset. We then observed antibody response to three oxPTM-INS neoepitope peptides (oxPTM-INSP) and evaluated their ability to stimulate both humoral and T cell responses in T1D. oxPTM-INS neo-antigenic epitopes, may be involved in the immunopathogenesis of Type 1 diabetes and potentially become targets for precision medicine.


11:45 am

Targeting the Undruggable: Identification and Early Development of Succinate-Modulating Therapies

Isabel Huber-Ruano, PhD, Scientific CEO and Co-Founder, Succipro SL

Succinate, a metabolite produced by both the host and the microbiota, is not a mere TCA metabolite since it plays roles in cellular signaling of an inflammation. Chronic elevations of succinate, observed in various disorders, contribute to disease progression, highlighting the need for interventions able to modulate its effects, which have so far been unsuccessful. At SUCCIPRO we are developing first-in-class drugs able to directly modulate succinate, an undruggable target to date. Current candidates are in the final stage of lead optimization, and this talk will cover the journey from early in silico identification to successful in vivo efficacy studies.


12:15 pmSponsored Presentation (Opportunity Available)

12:45 pmSession Break

12:50 pmLuncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:50 pmClose of Biologics for Immunology Indications Conference

6:30 pmRecommended Dinner Short Course

SC5: Targeting the Target: Aligning Target and Biologic Format Biology to Achieve Desired Outcomes

*Separate registration required. See short course page for details.

* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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更新履歴
2025/03/21
アジェンダ・講演者・スポンサー更新

表示する:

Engineering
工学ストリーム
Oncology
腫瘍ストリーム
Bispecific Antibodies
多重特異性ストリーム
Immunotherpary
免疫療法ストリーム
Expression
発現ストリーム
Analytical
分析法ストリーム
Immunogenicity
免疫原性ストリーム
Emerging Modalities
新興治療ストリーム
Machine Learning Stream
機械学習ストリーム

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